Introduction Duotrol Tablet belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes. Duotrol Tablet should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels. Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes. The most common side effect of Duotrol Tablet is low blood glucose levels (hypoglycemia). Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it’s important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include taste changes, nausea, diarrhea, stomach pain, headache, and upper respiratory tract infection. Some people may find that they put on weight with this medicine. You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function. Uses of Duotrol Tablet Type 2 diabetes mellitus Side effects of Duotrol Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you?re worried about them Common side effects of Duotrol Hypoglycemia (low blood glucose level) Taste change Nausea Diarrhea Stomach pain Headache Upper respiratory tract infection How to use Duotrol Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duotrol Tablet is to be taken with food. How Duotrol Tablet works Duotrol Tablet is a combination of two antidiabetic medicines: Glibenclamide and Metformin. Glibenclamide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body’s sensitivity to insulin. Safety Advice Alcohol UNSAFE It is unsafe to consume alcohol with Duotrol Tablet. Pregnancy SAFE IF PRESCRIBED Duotrol Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Breastfeeding SAFE IF PRESCRIBED Duotrol Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Driving CAUTION Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur. Kidney UNSAFE Duotrol Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor. Liver CAUTION Duotrol Tablet should be used with caution in patients with liver disease. Dose adjustment of Duotrol Tablet may be needed. Please consult your doctor. Duotrol Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
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